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pentobarbital will lessen the extent or outcome of buprenorphine, long-performing injection by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Intently. People who transfer to buprenorphine prolonged-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers needs to be monitored to be s